How OzmoCAP® Works
A trial subject swallows an OzmoCAP®, which is dosed like an ordinary capsule.
OzmoCAP® capsules transit rapidly through the esophagus and arrive in the stomach. In the stomach, the capsules start releasing the active ingredient. While drug release from OzmoCAP® capsules is independent of pH, the drug’s solubility may be impacted by the acidity of the stomach. The drug continues to be pumped out while the capsule remains in the stomach. The time in the stomach will vary based upon the subject species and fed versus fasted state (it is always significantly longer in the fed state).
OzmoCAP® capsules transit rapidly through the esophagus and arrive in the stomach. In the stomach, the capsules start releasing the active ingredient. While drug release from OzmoCAP® capsules is independent of pH, the drug’s solubility may be impacted by the acidity of the stomach. The drug continues to be pumped out while the capsule remains in the stomach. The time in the stomach will vary based upon the subject species and fed versus fasted state (always significantly longer in the fed state).
After exiting the stomach, OzmoCAP® capsules enter the small intestine and continue to pump out drug. Eventually, the capsules enter and continue to pump drug into the colon (large intestine). While the residence time in the colon can be long, in many cases, absorption of drugs is slow due to low water content, high pH, poor drug permeability, and drug efflux.
Using OzmoCAP® capsules with different release rates and dosed using different fed states, it is possible to determine if absorption in different portions of the GI tract will be significant. This helps determine the ideal release rate to meet the product design goals.